Technical Notes:

In many respects the catalytic profile of the Me BIPHEP ligands is similar to that of other atropisomeric diphosphines such as binap and its many analogs. The nature of the PRz group strongly influences the catalytic performance of the metal complexes. The rhodium and ruthenium MeO-BIPHEP catalysts are highly effective for the hydrogenation of various c=o, C=c and C=N bonds and several synthetically useful C-c coupling reactions.

1. See 15-0042

2.Ru and Ir catalyzed dynamic kinetic resolution for the synthesis of hydroxy, amino acid derivatives.

3. Ru-catalyzed asymmetric hydrogenation of ketones and alkenes.

4. Ir catalyzed enantioselective hydrogenation of heteroaromatic compounds.

5.Conjugate addition using 2-heteroaryl titanates and zinc reagents .

References:

1. Adv. Synth. C atal., 2004, 346, 842.

2.Org. Lett., 2006, 8, 4573.

3.Org. Process Res. Devel., 2001, 5, 438.

4.J. Am. C hem. Soc., 2003, 125, 10536.

5.Org. L ett., 2009, 1 1, 4200.