(R)-巴氯芬 , 98% , 是选择性 GABAB 受体激动剂
(R)-Baclofen, 98%, a selective GABAB receptor agonist
分子式: C10H12ClNO2
分子量: 213.66
纯度: 98%
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基本信息
安全信息
存储条件Freezer -20℃ |
化学和物理性质
产品描述
产品描述
(R)-baclofen是一种γ-氨基丁酸衍生物，主要用于治疗痉挛。
靶点（IC50 & Targe）
GABAR
体外研究
Baclofen is a skeletal muscle relaxant used in the treatment of spasticity of spinal and cerebral origin. Although it is marketed as a racemic mixture, only the baclofen R-enantiomer is stereospecifically active at so called GAGAB-receptors. Researchers believe that the enantiomers of baclofen have different properties. It is claimed that the R-(−)-enantiomer is about 100 times more active than the S-(+)-enantiomer.
参考文献
[1] Falch E, et al. J Neurochem, 1986, 47(3), 898-903.
[2] Penn RD, et al. Lancet, 1984, 1(8385), 1078.
