PD153035 , 98% , 有效EGFR抑制剂, Ki 和 IC50 值分别为6和25 pM
PD153035, 98%, a potent EGFR inhibitor with Ki and IC50 of 6 and 25 pM, respectively
分子式: C16H14BrN3O2
分子量: 360.21
纯度: 98%
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基本信息
英文别名SU-5271, AG1517, ZM 252868 | |
中文别名SU-5271, AG1517, ZM 252868 | |
MDL编码MFCD00934896 |
安全信息
存储条件Freezer -20℃ | Symbol  |
Signal WordWarning | Hazard StatementsH315 H319 H335 |
Precautionary StatementsP280 P321 P261 P271 P319 P405 P501 P302+P352 P332+P317 P362+P364 P264+P265 P305+P351+P338 P337+P317 P304+P340 P403+P233 | |
化学和物理性质
产品描述
产品描述
PD153035是一种特定的、有效的EGFR抑制剂，Ki值为5.2 pM。
靶点（IC50 & Targe）
EGFR
体外研究
PD153035 inhibits EGF-dependent EGF receptor phosphorylation and suppresses the proliferation and cbonogenicity of a wide panel of EGF receptor-overexpressing human cancer cell lines. EGF receptor autophosphorylation in response to exogenous EGF can be completely inhibited at PD153035 concentrations of >75 nM in cells overexpressing the EGF receptor[1].
参考文献
[1] Bos M, et al. Clin Cancer Res. 1997, 3(11):2099-106.
[2] Fry DW, et al. Science. 1994, 265(5175):1093-5.
