蛋白激酶仰制剂 , 98% , 一种能透过细胞的,有效的,特异性的,可逆的,ATP 竞争性的蛋白酶 K (PKA) 的抑制剂,其 Ki 值为 60 nM
KT5720, 98%, a cell-permeable, potent, specific, reversible, ATP-competitive inhibitor of protein kinase A (PKA), with a Ki of 60 nM
分子式: C32H31N3O5
分子量: 537.61
纯度: 98%
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基本信息
英文别名(9S,10S,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3′,2′,1′-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid hexyl ester | |
MDL编码MFCD00132118 |
安全信息
存储条件Freezer -20℃ | Precautionary StatementsP262 |
WGK Germany3 | |
化学和物理性质
产品描述
产品描述
KT5720 is a cell-permeable, potent, specific, reversible, ATP-competitive inhibitor of protein kinase A (PKA), with a Ki of 60 nM[1][2].
靶点（IC50 & Targe）
Ki: 60 nM (PKA)[1][2].
参考文献
[1]. Davies SP, et al. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105.
[2]. Murray A, et al. Pharmacological PKA inhibition: all may not be what it seems. Sci Signal. 2008 Jun 3;1(22):re4.
