制蚜菌素 , 是真菌的代谢物, 是一种组蛋白脱乙酰酶 (HDAC) 抑制剂,具有抗寄生虫活性和广谱的抗增殖活性
Apicidin, a fungal metabolite, acts as a histone deacetylase (HDAC) inhibitor, with antiparasitic activity and a broad spectrum antiproliferative activity
分子式: C34H49N5O6
分子量: 623.78
纯度: N/A
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基本信息
英文别名Cyclo[(2S)-2-amino-8-oxodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinexcarbonyl | |
MDL编码MFCD03452661 |
安全信息
存储条件Freezer -20℃ | Symbol  |
Signal WordDanger | Hazard StatementsH300 H310 H330 |
Precautionary StatementsP264 P270 P321 P330 P405 P501 P262 P280 P260 P271 P284 P320 P301+P316 P302+P352 P361+P364 P304+P340 P403+P233 | |
UN2811 | Hazard Class6.1 |
Packing GroupII | WGK Germany3 |
化学和物理性质
产品描述
产品描述
Apicidin (OSI 2040) is a fungal metabolite, acts as a histone deacetylase (HDAC) inhibitor, with antiparasitic activity and a broad spectrum antiproliferative activity[1].
靶点（IC50 & Targe）
HDAC[1]
参考文献
[1]. Han JW, et al. Apicidin, a histone deacetylase inhibitor, inhibits proliferation of tumor cells via induction of p21WAF1/Cip1 and gelsolin. Cancer Res. 2000 Nov 1;60(21):6068-74.
