去水淫羊藿黄素 , 97% , 是 Epimedium Genusis 的异戊二烯类黄酮衍生物,有效抑制 K562 细胞 (IC50 为 8 µM) 和原代 CML 细胞 (对 CML-CP 的 IC50 值为 13.4 µM,对 CML-BC 的 IC50 值为 18 µM) 的增殖.Icaritin 可以调节 MAPK/ERK/JNK 和 JAK2/STAT3/AKT 信号传导,并具有增强成骨的作用
Icaritin, 97%, potently inhibits proliferation of K562 cells (IC50 of 8 µM) and primary CML cells (IC50 of 13.4 µM for CML-CP and 18 µM for CML-BC). Icaritin can regulate MAPK/ERK/JNK and JAK2/STAT3 /AKT signalings
分子式: C21H20O6
分子量: 368.38
纯度: 97%
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基本信息
英文别名3,5,7-trihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)chromen-4-one | |
中文别名脱水淫羊藿素 | |
n20D1.656 | MDL编码MFCD00210516 |
Reaxys-RN (Beilstein)347627 | |
安全信息
存储条件Store at 2-8℃ | RTECSDJ3100870 |
化学和物理性质
MP239 | BP582 |
FP206.7 | Density1.359 |
产品描述
产品描述
Anhydroicaritin, a prenylated flavonoid natural product, is commonly recognized as one of the effective compounds of Epimedii Herba and exhibits a variety of biological activities, such as activation of cancer cell apoptosis and inhibition of growth, protection against beta amyloid-induced neurotoxicity, and promotion of neuronal and cardiac cellular differentiation. It is a potent inhibitor of transcription factor SREBPs.
