LH846 , 98% , 一种选择性的 CKIδ 抑制剂
LH846, 98%, a selective inhibitor of CKIδ
分子式: C16H13ClN2OS
分子量: 316.81
纯度: 98%
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基本信息
安全信息
存储条件Freezer -20℃ |
化学和物理性质
产品描述
产品描述
LH846 is a selective inhibitor of CKIδ, with an IC50 of 290 nM, and less potently inhibits CKIα and CKIε, with IC50s of 2.5 μM and 1.3 μM, respectively.
靶点（IC50 & Targe）
CK1
体外研究
LH846 is a potent inhibitor of CKIδ, with an IC50 of 290 nM, less potently inhibits CKIα and CKIε, with IC50s of 2.5 μM and 1.3 μM, respectively, and has no effect on CK2. LH846 (3 or 10 μM) inhibits CKIδ-dependent phosphorylation of PER1 in HEK293T cells[1].
参考文献
[1]. Lee JW, et al. A small molecule modulates circadian rhythms through phosphorylation of the period protein. Angew Chem Int Ed Engl. 2011 Nov 4;50(45):10608-11.
