纳米药物分析相关产品推荐-百灵威

纳米药物是指通过纳米技术将活性成分制备为纳米级颗粒（1-1000 nm）或与纳米材料结合形成的药物制剂，包括脂质体、纳米乳、聚合物胶束等类型。其独特的小尺寸效应和高比表面积赋予其突破生物屏障、控制药物释放、靶向递送等优势，已在肿瘤治疗、抗感染等领域展现显著临床价值^[1]。

纳米药物的理化性质（如粒径、表面电荷）直接影响其体内分布、代谢及疗效，因此，建立科学的质量控制体系是确保纳米药物安全性、有效性及临床转化的核心前提。根据最新的《纳米药物质量控制研究技术指导原则》，纳米药物的检测指标分为制剂特性和纳米特性两类。制剂特性分为药物鉴别、含量测定、溶残等指标，通常使用高效液相（HPLC）、气相（GC）、核磁共振、紫外分光光度仪进行分析。纳米特性为粒径大小及分布、结构及形态、Zeta电位、包封率与载药量、体外溶出与释放，分析方法有动态光散射法（DLS）、透射电镜（TEM）、扫描电镜（SEM）、拉曼光谱（Raman）、X射线衍射法（XRD）、偏振光显微镜法、电泳、透析、流通池、离心。临床上采用低温透射电镜（cryo-TEM）和激光共聚焦显微镜观测量子点（QDs）荧光探针标记药物或用SPECT/CT成像系统观测核素标记药物。

图1 BAY-876/V-9302@HSA纳米颗粒的合成及诱导细胞焦亡示意图^[1].

百灵威可提供品类齐全的纳米药物分析的相关产品，包括显色剂、标记试剂、分散剂、固定剂和脱水剂、光谱溶剂、电泳、液相色谱、核磁共振波谱、红外光谱、拉曼光谱、制样用品、药物相关标准对照品、缓冲液、比色皿及其他相关耗材，种类齐全，质控严格，批次稳定性优异，产品详情如下：

荧光染料

品名	CAS	货号
Fluorescein isothiocyanate isomer I, 95% 异硫氰酸荧光素异构体 I	3326-32-7	255493
Sulforhodamine B acid chloride, mixture of isomers 磺基罗丹明B酸氯	62796-29-6	138575
Rhodamine 110, 98.5% 罗丹明110	13558-31-1	196875
Rhodamine B, 96% 罗丹明B	81-88-9	603231
Sulfo-Cy3-COOH, 95% 水溶性花菁素Cy3羧酸	146368-13-0	1871751
Sulfo-cyanine5 carboxylic acid, 95% 磺基-Cy5 羧酸	146368-11-8	1871752
Fluorescein 5(6)-isothiocyanate, 95%, for fluorescence, mixture of 5- and 6- isomers 5(6)-异硫氰酸荧光素	27072-45-3	194222
Rhodamine 6G, indicator 罗丹明 6G	989-38-8	151183

品名	CAS	货号
Dodecyl sodium sulfate, 99%, for ion pair chromatography 十二烷基硫酸钠	151-21-3	953543^新

固定剂和脱水剂

品名	CAS	货号
Glutaraldehyde, 50 wt.% solution in H2O 戊二醛	111-30-8	902042 危化品
Glutaraldehyde 25 % solution in water, for electron microscopy, standard grade 戊二醛	111-30-8	2311501 危化品

光谱溶剂

品名	CAS	货号
Acetonitrile, 99.9%, for spectroscopy 乙腈	75-05-8	979255 危化品
Cyclohexane, 99.5%, for spectroscopy 环己烷	110-82-7	924973 危化品
Dichloromethane, 99.5%, for spectroscopy 二氯甲烷	75-09-2	954870 危化品
Isopropanol, 99.5%, for spectroscopy 异丙醇	67-63-0	900696 危化品
Methanol, 99.8%, for spectroscopy 甲醇	67-56-1	941203 危化品
n-Pentane, 98%, for spectroscopy 正戊烷	109-66-0	978892 危化品
Tetrahydrofuran, 99.9%, for spectroscopy 四氢呋喃	109-99-9	916766 危化品

显色剂

品名	CAS	货号
Dithizone, 78%, for analysis 双硫腙	60-10-6	979949
Xylenol Orange 二甲酚橙	1202864-39-8	B0477
4-(2-Pyridylazo)resorcinol, 95% 4-(2-吡啶偶氮)间苯二酚	1141-59-9	289448
2-(5-Bromo-2-pyridylazo)-5-(diethylamino)phenol, 97% 2-(5-溴-2-吡啶偶氮)-5-二乙氨基苯酚	14337-53-2	497619
Arsenazo III [Spectrophotometric reagent for U, Th, Zr and other metals, Indicator for the precipitation titration of SO4 with Ba] 偶氮胂Ⅲ [铀,钍,锆和其它金属类用分光光度试剂,及硫酸根用钡沉淀滴定的指示剂]	1668-00-4	A5009
1,5-Diphenylcarbazide, for analysis 1,5-二苯基卡巴肼	140-22-7	971299
Sodium diethyldithiocarbamate, 98% 二乙基二硫代氨基甲酸钠	148-18-5	271275
1,10-Phenanthroline monohydrate, 99%, for analysis 1,10-菲罗啉一水合物	5144-89-8	959335
Dimethylglyoxime, 98%, for analysis 二甲基乙二肟	95-45-4	912719
Chromeazurol S, Indicator 铬天青S	1667-99-8	366257

SDS-PAGE电泳

品名	CAS	货号
2-Mercaptoethanol, 99%, for electrophoresis and molecular biology 2-巯基乙醇	60-24-2	249096^促危化品
Acrylamide, 99%, Electrophoresis Grade 丙烯酰胺	79-06-1	911990 危化品
Ammonium persulfate, 98%, for electrophoresis 过硫酸铵	7727-54-0	977625 危化品
Bromophenol Blue, for analysis, Indicator 溴酚蓝	115-39-9	978967
N,N,N',N'-Tetramethylethylenediamine, 99%, extra pure N,N,N',N'-四甲基乙二胺	110-18-9	913080 危化品
Tris(hydroxymethyl)aminomethane, 99.9%, for Electrophoresis 三(羟甲基)氨基甲烷	77-86-1	989416

品名	CAS	货号
Acetonitrile, 99.9%, LC-MS 乙腈	75-05-8	932537 危化品
Methanol, 99.9%, LC-MS 甲醇	67-56-1	952707 危化品
Water, LC-MS 水	7732-18-5	965057
Ethanol, 99.8%, HPLC/ACS 乙醇	64-17-5	441863 危化品
Formic acid, 98%, for LC-MS 甲酸	64-18-6	942988 危化品
Ammonium acetate, 99%, eluent additive for LC-MS 乙酸铵	631-61-8	992378
α-Cyano-4-hydroxycinnamic acid, 99% α-氰基-4-羟基肉桂酸	28166-41-8	947196
Ferulic acid, 99% 阿魏酸	1135-24-6	408508
Caffeic acid, 99%, predominantly trans 咖啡酸	331-39-5	247526
2-(4-Hydroxyphenylazo)benzoic acid, 98% 2-(4-羟基苯唑)苯甲酸	1634-82-8	604440
3-Hydroxypicolinic acid, 98% 3-羟基-2-吡啶甲酸	874-24-8	559198
1,8-Dihydroxyanthracen-9(10H)-One	1143-38-0	OR1009295

品名	CAS	货号
Acetonitrile-d3, 99.8 atom%D 氘代乙腈-d3	2206-26-0	236920^促
Acetone-d6, 99.8 atom%D 氘代丙酮-d6	666-52-4	210730^促
Chloroform-d, 99.8 atom%D, contains 0.03% v/v TMS 氘代氯仿	865-49-6	995425^促
Chloroform-d, 99.8 atom%D, contains 0.03% v/v TMS, stabilized with silver foil 氘代氯仿	865-49-6	167915^促
Tetramethylsilane [for NMR] 四甲基硅烷 [用于核磁共振]	75-76-3	T0154 危化品

品名	CAS	货号
Potassium bromide, 99%, for analysis 溴化钾	7758-02-3	994477
Tetrahydrofuran, 99.9%, for spectroscopy 四氢呋喃	109-99-9	916766 危化品
n-Pentane, 98%, for spectroscopy 正戊烷	109-66-0	978892 危化品
Cyclohexane, 99.5%, for spectroscopy 环己烷	110-82-7	924973 危化品

品名	CAS	货号
Oil soluble spherical gold nanoparticles, 0.05 mg/mL in xylenes, d=100±5nm, surface group: arenes 油溶性球形金纳米颗粒	/	9229233
Water soluble spherical gold nanoparticles, 0.05 mg/mL in ultrapure water, d=10±3nm, surface group: citrate, λ=519±2nm, OD: 0.8±0.1 水溶性球形金纳米颗粒	7440-57-5	919290
Spherical gold nanoparticles modified with PEG, 0.05 mg/mL in ultrapure water, d=100±5nm, surface group: —PEG—COOH PEG化球形金纳米颗粒	/	9229261
Spherical gold nanoparticles modified with PEI, 0.05 mg/mL in ultrapure water, alternative diameter: 5-200nm optional, surface group: PEI(MW=70000) PEI修饰的球形金纳米颗粒	/	9229273
Gold, 99%, 0.1 mg/mL dispersion in H2O, diam.: 40±3 nm, length: 80±10 nm, λ: 660±5 nm 金	7440-57-5	129871
Gold nanorods, particle size:14nm×50nm (diam. × L ),80 μg/mL in H2O 金纳米棒	7440-57-5	928224
Oil soluble gold nanorods, 0.1 mg/mL in in xylenes, surface group: arenes, λ=1260±15nm 油溶性金纳米棒	/	9229304

缓冲溶液

品名	CAS	货号
Buffer solution pH=7.00 (20 ℃), Potassium dihydrogen phosphate/Disodium hydrogen phosphate pH缓冲液, pH=7.00 (20 ℃)	/	696935
Potassium phosphate dibasic, 99%, ACS reagent 磷酸氢二钾	7758-11-4	127325
Imidazole, 99% 咪唑	288-32-4	149443
Sodium phosphate dibasic, 99%, for bio 磷酸氢二钠	7558-79-4	284367
2-(N-Morpholino)ethanesulfonic acid, 99% 2-(N-吗啉基)乙磺酸	4432-31-9	100282
Potassium phosphate tribasic, 99%, reagent grade 磷酸三钾	7778-53-2	949522
Buffer solution pH=7.00 (20 ℃), Potassium dihydrogen phosphate/Disodium hydrogen phosphate pH缓冲液, pH=7.00 (20 ℃)	/	696935
Tris(hydroxymethyl)aminomethane hydrochloride, 99%, for bio 三(羟甲基)氨基甲烷盐酸盐	1185-53-1	165488^促

品名	CAS	货号
Microporous membrane filters, CA, non-sterile, white, Ф50, 0.22μm, 50 pcs/pack 微孔滤膜	/	954596
Microporous membrane filters, MCE, white, sterile, Ф47, 0.22μm, 200 pcs/pack 微孔滤膜	/	932350
Microporous membrane filters, hydrophilic PP, non-sterile, white, Ф47, 0.22μm, 50 pcs/pack 微孔滤膜	/	986749

比色皿

品名	CAS	货号
Standard cuvettes with lid, 3.5ml, 45×12.5×12.5, ES Quartz glass, 190-2500nm 标准带盖圆底比色皿, 3.5ml	/	691130
Standard round-bottom cuvettes with lid, 10.5ml, 45×12.5×32.5, IR quartz glass, 250-3500nm 标准带盖圆底比色皿, 10.5ml	/	999852
Standard round-bottom cuvettes with lid, 14ml, 45×12.5×42.5, IR quartz glass, 250-3500nm 标准带盖圆底比色皿, 14ml	/	960592
Standard round-bottom cuvettes with lid, 17ml, 45×12.5×52.5, Optical glass, 340-2500nm 标准带盖圆底比色皿, 17ml	/	939514
Standard round-bottom cuvettes with lid, 35ml, 45×12.5×102.5, Optical glass, 340-2500nm 标准带盖圆底比色皿, 35ml	/	920524
Standard round-bottom cuvettes with lid, 7ml, 45×12.5×22.5, ES quartz glass, 190-2500nm 标准带盖圆底比色皿, 7ml	/	9108677

品名	CAS	货号
C8 HPLC column, 150×4.6 mm 5 μm, 120 Å, pH 3-7.5 C8液相色谱柱	/	1122770
5 mm NMR Economy Sample Tube w/ Cap, 7″, High-Throughput 5毫米，高通量经济型核磁管，7英寸	/	1001281
96 deep well plate, 2.0 ml, transparent,sterile, round-well,U-shaped Bottom,low retention, 5 pcs 96孔深孔板	/	901814
Single-channel mechanical pipettor, Volume range: 0.5 - 10 μL, Increment: 0.1 μL 单道手动可调移液器	/	1122421
Centrifuge tubes, 1.5 mL, clear, 500 tubes/pack 离心管	/	915664
Pipette tips, 10 μL, clear, 1000 tips/pack 移液器吸头	/	920067
Agate Mortar and Pestle, 65mm OD 玛瑙研钵和棒, 65mm外径	/	039791
Plastic spoon, 200mm, PP 塑料药勺	/	918317

参考文献

1.Synergistic Apoptosis-Ferroptosis: Oxaliplatin loaded amorphous iron oxide nanoparticles for High-efficiency therapy of orthotopic pancreatic cancer and CA19-9 levels decrease。Yilong Li，Xinlong Wang, Binbin Ding, Cong He, https://doi.org/10.1016/j.cej.2023.142690，2023.