Amine and Isocyanate Reaction-百灵威

Amine and Isocyanate Reaction

时间: Invalid Date

作者: 百灵威

Isocyanate reacts with 1° or 2° amines to make urea derivatives at room temperature. The amine attacks the isocyanate carbon and a proton transfer from the amine nitrogen to the isocyanate nitrogen produces urea.

Reagents: Solvent (DMF, THF, DCM)
Reactant: 1° or 2° Amine, Isocyanate
Product: Urea Derivative
Type of Reaction: Nucleophilic Addition
Bond Formation: N-C
Temperature: RT

Mechanism

Top Citations

Kinetics and Mechanism of Urethane Reactions: Phenyl Isocyanate–Alcohol Systems. Journal of Polymer Science Part A: Polymer Chemistry 1987, 25 (9), 2543–2559.

Kinetics of Isocyanate Amine Reactions. Journal of Applied Polymer Science. 1987, 34 (7), 2409–2432.

Three Fundamental Mechanisms of Base-Catalysed Reactions of Isocyanates with Hydrogen-Acidic Compounds. J. Chem. Soc., Perkin Trans. 2 1994, No. 3, 599–608.

Related Reactions

Curtius Rearrangement

Hofmann Rearrangement

Related Compounds

DMF (CAS 68-12-2)

THF (CAS 109-99-9)

DCM (CAS 75-09-2)

Amine

Isocyanate