Ester and Amine Reaction-百灵威

Ester and Amine Reaction

时间: Invalid Date

作者: 百灵威

Esters and amines or ammonia make amides under mild conditions. The nucleophilic amine attacks the carbonyl, followed by a proton transfer step that facilitates the removal of an alcohol, forming the amide.

Reactant: Ester, Amine or Ammonia
Product: Amide, Alcohol
Type of Reaction: Nucleophilic Acyl Substitution
Bond Formation: O=C-NH₂

Mechanism

Top Citations

Formation of Non-Amidine Products in the Reaction of Primary Amines with Imido Esters. Biochemical and Biophysical Research Communications 1975, 67 (1), 126–132.

Primary Amine-Thioureas Based on Tert-Butyl Esters of Natural Amino Acids as Organocatalysts for the Michael Reaction. Advanced Synthesis & Catalysis. 2009, 351 (9), 1355–1362.

Synthesis of Amides from Esters and Amines with Liberation of H2 under Neutral Conditions. J. Am. Chem. Soc. 2011, 133 (6), 1682–1685.

Related Compounds

Ester

Amine