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新型带甲基侧链手性试剂,构筑复杂手性化合物

带甲基侧链手性试剂广泛存在于具有生物活性的天然产物分子中,是合成具有特殊生物活性的天然产物和药物分子的重要原料,如抗肿瘤类医药 [1-2] 、群柱虫内酯Clavulactone及其类似物 [3] 、昆虫信息素 [4-6] 、香料等。

百灵威可提供全新带甲基侧链手性试剂,化学纯度及光学纯度高,现货供应,助力医药、香料合成化学家快速、有效地解决具有特殊生理活性天然复杂分子内多个手性构筑的大难题!

  • 新颖的手性中心,得到新颖的目标产物;
  • 碳链结构短,可更加灵活地对先导物进行结构改造;
  • 有效降低合成成本。
  1. McKenna, Jeffrey; et al. Assignee Signal Pharmaceuticals, LLC, USA 2007.
  2. Tian, Weisheng; . et. al. Peop. Rep.China 2011.
  3. Zhu, Qiang ; et al.Journal of Organic Chemistry (2001), 66(8), 2692-2699.
  4. Coppel, H. C. et al Science 1976, 192, 51.
  5. Hedenström, E. et al Tetrahedron 1992, 48, 3139.
  6. Wang Z.K. et. al Tetrahedron Lett., 2007, 48, 7549

1351507
155887-05-1
(R)-3-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2-methylpropan-1-ol, 95%, ee: 98%
(R)-3-((R)-2,2-二甲基-1,3-二氧五环-4-基)-2-甲基-1-丙醇, ee: 98%
1351508
1245644-03-4
Methyl (R)-5-benzyloxy-4-methyl-2-oxo-pentanoate, 95%, ee: 98%
(R)-5-苄氧基-4-甲基-2-氧代-戊酸甲酯, ee: 98%
1351511
104265-24-9
(R)-4-Benzyloxy-3-methylbutyronitrile, 98%, ee: 98%
(R)-4-苄氧基-3-甲基丁腈, ee: 98%

手性辅助剂

250526
131685-53-5
(R)-(-)-4-Benzyl-3-propionyl-2-oxazolidinone, 99%, ee: 99%
(R)-(-)-4-苄基-3-丙酰基-2-噁唑烷酮, ee: 99%
290117
171877-39-7
(S)-4-Benzylthiazolidine-2-thione, 99%, ee: 99%
(S)-4-苄基噻唑啉-2-硫酮, ee: 99%
956078
196929-78-9
(R)-(+)-tert-Butylsulfinamide, 98%
(R)-(+)-叔丁基亚磺酰胺
166246
191090-40-1
(R)-(+)-5,5-Diphenyl-4-benzyl-2-oxazolidinone, 98%, ee: 98%
(R)-(+)-5,5-二苯基-4-苄基-2-噁唑烷酮, ee: 98%
343112
223906-37-4
((R)-(+)-5,5-Diphenyl-4-methyl-2-oxazolidinone, 97%
(R)-(+)-5,5-二苯基-4-甲基-2-噁唑烷酮
339256
86286-50-2
(4R,5S)-(+)-cis-4,5-Diphenyl-2-oxazolidinone, 98%, ee: 98%
(4R,5S)-(+)-顺式-4,5-二苯基-2-唑烷酮, ee: 98%
553289
157636-81-2
(R)-(-)-4-(1H-Indol-3-ylmethyl)-2-oxazolidinone, 98%, ee: 98%
(R)-(-)-4-(1H-吲哚-3-甲基)-2-噁唑烷酮, ee: 98%
301644
184346-45-0
(S)-(-)-4-Isopropyl-5,5-diphenyl-2-oxazolidinone, 98%, ee: 99%
(S)-(-)-4-异丙基-5,5-二苯基-2-噁唑烷酮, ee: 99%
233653
77877-19-1
(S)-(+)-4-Isopropyl-3-propionyl-2-oxazolidinone, 98%, ee: 98%
(S)-(+)-4-异丙基-3-丙酰基-2-噁唑烷酮, ee: 98%