卢华老师科研成果 | 新型荧光染料—BODIPY，品种多，应用广

氟化硼二吡咯(Dipyrromethene Boron Difluoride，简称BODIPY)荧光物质是一类新型的染料，与传统的荧光素、罗丹明、菁类、稀土配合物类荧光染料相比，具有高荧光量子产率、高摩尔消光系数、良好的光稳定性、对pH不敏感等优点^[1]。研究发现通过在BODIPY共轭骨架的各取代位上引入不同的取代基可得到一系列具有不同功能的衍生物，产品可作为离子探针、分子探针、荧光标记、光动力疗法用光敏剂、分子砌块等广泛应用于环境监测和生命科学等领域^[2-5]。

杭州师范大学卢华老师研发了60余种BODIPY系列荧光染料，产品种类丰富，价格具有竞争力，且批次间稳定性良好。

BODIPY系列染料^[4]

1. Karolin J, Johansson L B, Strandberg L, et al. Fluorescence and absorption spectroscopic properties of dipyrrometheneboron difluoride (BODIPY) derivatives in liquids, lipid-membranes, and proteins. Journal of the American Chemical Society, 1994, 116(17): 7801-7806.
2. Loudet A, Burgess K. BODIPY dyes and their derivatives: syntheses and spectroscopic properties. Chemical reviews, 2007, 107(11): 4891-4932.
3. Boens N, Leen V, Dehaen W. Fluorescent indicators based on BODIPY. Chemical Society Reviews, 2012, 41(3): 1130-1172.
4. Lu H, Mack J, Yang Y, et al. Structural modification strategies for the rational design of red/NIR region BODIPYs. Chemical Society Reviews, 2014, 43(13): 4778-4823.
5. Kowada T, Maeda H, Kikuchi K. BODIPY-based probes for the fluorescence imaging of biomolecules in living cells. Chemical Society Reviews, 2015, 44(14): 4953-4972.

2332167

1134484-25-5

4,4-Difluoro-8-​pyridyl-1,3,5,7-tetramethyl-4-bora-3a,4a-diaza-s-indacene, 98%

2332222

1996627-88-3

NIR-BODIPYs-free acid, 97%

1278124

121207-31-6

1,3,5,7,8-Pentamethyl-BODIPY, 97%

1278126

131083-16-4

1,3,5,7,8-Pentamethyl-2,6-diethylpyrromethene-difluoroborate, 97%

2332185

1478660-41-1

1,3,5,7,8-Pentamethyl-2,6-dipyridyl-4,4-difluoro-4-bora-3a,4a-diaza-s-indacene, 97%

2332162

180156-50-7

8-​Phenyl-​4,​4-​difluoroboradiazaind​acene, 97%

2332206

1825368-13-5

1,3,5,7-Tetramethyl-2,6-diiodo-C3-SE-BODIPYs, 97%

2332163

194235-40-0

1,3,5,7-Tetramethyl-8-phenyl-4,4-difluoroboradiazaindacene, 97%