细胞信号传导——NF-κB信号通路相关产品精选-百灵威

NF-κB（Nuclear Factor kappa-light-chain-enhancer of activated B cells）信号通路是在细胞信号传递中极为重要的途径，其在细胞应对应激、炎症和感染等信号的核心转导系统，通过调控基因表达协调免疫应答、炎症反应和细胞存活。该通路包含经典（主要介导免疫炎症）和非经典（调控淋巴细胞发育）两条激活路径，形成精密的双层调控网络。核因子蛋白起到二聚化转录因子的作用，可调节基因表达，并影响各种不同的生物学过程，包括先天和适应性免疫、炎症、应激反应、B细胞发育和淋巴器官的形成。NF-κB的异常激活与多种疾病的发生和发展密切相关，包括自身免疫疾病、炎症反应性疾病、以及某些类型的癌症等。

NF-κB信号通路作为连接外界刺激与细胞应答的桥梁，其研究不仅深化了对免疫炎症机制的理解，更催生了多种疾病治疗新策略。从炎症控制到肿瘤治疗，从免疫调节到药物开发，该通路的转化价值持续显现。

百灵威提供NF-κB信号通路中的小分子抑制剂和激动剂等活性化合物，助力信号通路研究。

靶点信息清晰明确，便于选择；

严格的质检，确保产品高纯度、高品质；

生物活性经多客户验证；

性价比高：每个产品可节约5%-20%成本。

小分子抑制剂、激动剂等活性化合物

品名	CAS	货号
5-Aminosalicylic acid, 98.5%, an NF-kB and PGDH inhibitor 5-氨基水杨酸	89-57-6	236213
Thalidomide, 98%, initially promoted as a sedative, inhibits cereblon (CRBN), with a Kd of ∼250 nM, and has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties 沙利度胺	50-35-1	374892
Pomalidomide, 99%, a inhibitor of TNF-α 泊马度胺	19171-19-8	911951
BX795, 98%, a potent and selective dual inhibitor of TBK1/PDK1 BX795抑制剂	702675-74-9	1232532
IKK 16, 97%, a selective IκB kinase (IKK) inhibitor for IKK2, IKK complex and IKK1 IKK 16抑制剂	873225-46-8	1561574
Bay 11-7085, 98%, an inhibitor of NF-κB activation and phosphorylation of IκBα; it stabilizes IκBα with an IC50 of 10 μM Bay 11-7085	196309-76-9	157946
β Cell proliferation agonist WS3, 98%, a novel small molecule that promotes β cell proliferation β Cell proliferation agonist WS3	1421227-52-2	1835016
WS6, 98%, a novel small molecule that promotes β cell proliferation WS6	1421227-53-3	1866861
MLN120B, 99%, a specific, ATP competitive IKKβ inhibitor with an IC50 of 60 nM MLN120B	783348-36-7	2061873
LY2409881 trihydrochloride, 98%, a selective IκB kinase β (IKK2) inhibitor LY2409881 trihydrochloride	946518-60-1	2276015
GSK583, 98%, a highly potent and selective inhibitor of RIP2 Kinase GSK583抑制剂	1346547-00-9	2276072

蛋白免疫印迹（WB）

品名	CAS	货号
Bovine serum albumin, 98%, Australia origin, low IgG, low fatty acid 牛血清白蛋白	9048-46-8	109636
Acrylamide, 99% 丙烯酰胺	79-06-1	166974 危化品
Super ECL Plus Detection Reagent (component A), used with 1912570 Super ECL Plus超敏发光液(A液)	/	946079
Super ECL Plus Detection Reagent (component B), used with 946079 Super ECL Plus超敏发光液(B液)	/	1912570
Sodium dodecyl sulfate, 99%, for biochemistry 十二烷基硫酸钠	151-21-3	105893^促

核心生化试剂

品名	CAS	货号
Superior fetal bovine serum 精制胎牛血清	/	9410422
4-Nonylphenyl-polyethylene glycol 4-壬基苯基-聚乙二醇	9016-45-9	931454 危化品
2-Mercaptoethanol, 99%, for electrophoresis and molecular biology 2-巯基乙醇	60-24-2	249096^促危化品
D-(+)-Glucose, 99%, for bio D-(+)-葡萄糖	50-99-7	936778^促
Proteinase K, for bio, 30-40U/mg 蛋白酶 K	39450-01-6	968706
Acrylamide, 99% 丙烯酰胺	79-06-1	166974 危化品
Sodium dodecyl sulfate, 99%, for electrophoresis 十二烷基硫酸钠	151-21-3	160975^促

品名	CAS	货号
Single-channel mechanical pipettor, Volume range: 100 - 1000 μL, Increment: 5.0 μL 单道手动可调移液器	/	1122427
Pipette tips, 1000 μL, blue, 1000 tips/pack 移液器吸头	/	672890
96-well UV-transparent microplate, Non-sterile, bagged, black without lid, 5 tips/bag, 10 bags/case 96孔紫外可透微孔板	/	9478529
96-well non-removable high-binding ELISA plate, Bagged, transparent without lid, 5 tips/bag, 20 bags/case 96孔不可拆高结合力酶标板	/	9478546
Pipette tips, 10 μL, clear, low Retention, 1000 tips/pack 移液器吸头	/	1438538