质谱在药物代谢和药物动力学中的应用

时间: 2024-12-11
作者: 百灵威
分享:
质谱在药物代谢和药物动力学中的应用|百灵威-百灵威
    新药的发现和开发过程需要评价大批先导化合物时的吸收、分布、代谢和排泄(ADME)性质。质谱技术具有灵敏度高、样品用量少、分析速度快、易于自动化等特点,是药物代谢和药物动力学研究的重要手段之一,根据所获得的数据可以确定药物在体内的运行与转化。质谱分析适用于多种类型的药物或代谢产物,对于某些药物,需要通过衍生化的方法改善其离子化行为。此外,色谱共流出组分对待测物的质谱信号的抑制或增强是质谱定量分析的主要问题,即基质效应,它可削弱方法的线性和分析结果的重现性,因此在定量方法确证和应用之前,必须解决基质效应问题。通常可采用稳定同位素内标进行定量分析。因为稳定同位素类化合物与被分析物具有几乎相同的物理化学性质,二者的色谱保留时间、离子化程度和质谱裂解方式基本一致,可以有效补偿基质效应带来的误差。
    百灵威可提供多种质谱研究常用产品,包括溶剂、衍生化试剂、流动相添加剂、质谱标准品、质谱基质、同位素标记物、耗材系列产品,以及药物代谢和药物动力学分析用氘代内标,多数产品纯度99%以上,同位素丰度≥ 98%,质控严格,批次稳定性优异。
溶剂
品名 CAS 货号
Acetonitrile, 99.9%, LC-MS
乙腈
75-05-8 932537
危化品
Ethanol, 99.8%, HPLC/ACS
乙醇
64-17-5 441863
危化品
Methanol, 99.9%, LC-MS
甲醇
67-56-1 952707
危化品
Water, LC-MS
7732-18-5 965057
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衍生化试剂
品名 CAS 货号
N2,N2,N4,N4-Tetramethyl-6-(4-(chloride-1-ylsulfonyl)phenyl)-1,3,5-triazine-2,4-diamine(TMT-Cl), 98%
N2,N2,N4,N4-四甲基-2,4-二氨基-6-(4-苯基磺酰氯)-1,3,5-三嗪
/ 9415861
N2,N2,N4,N4-Tetramethyl-6-(4-(hydrazine-1-ylsulfonyl)phenyl)-1,3,5-triazine-2,4-diamine(TMT-Hz), 98%
N2,N2,N4,N4-四甲基-2,4-二氨基-6-(4-苯基磺酰肼)-1,3,5-三嗪
/ 9415862
N2,N2,N4,N4-Tetramethyl-6-(4-(piperazin-1-ylsulfonyl)phenyl)-1,3,5-triazine-2,4-diamine(TMT-PP), 98%
N2,N2,N4,N4-四甲基-2,4-二氨基-6-(4-苯基磺酰哌嗪)-1,3,5-三嗪
/ 9415860
Dansyl chloride, 98%
丹磺酰氯
605-65-2 164579
Girard's Reagent P, 98%
吉拉德试剂 P
1126-58-5 341056
Girard's Reagent T, 98%
吉拉尔特试剂T
123-46-6 509681
N,N-Dimethylglycine hydrazide DiHCl
N,N-二甲基甘氨酸酰肼二盐酸盐
5787-71-3 F238487
O-(Carboxymethyl)hydroxylamine hemihydrochloride, 98%, derivatization grade
O-(羧甲基)羟胺半盐酸盐
2921-14-4 148928
p-Toluenesulfonyl isocyanate, 96%
对甲苯磺酰 异氰酸酯
4083-64-1 303168
Succinimidyl 4-[3,5-Dimethyl-4-(4-nitrobenzyloxy)phenyl]-4-oxobutyrate
4-[3,5-二甲基-4-(4-硝基苄氧基)苯基]-4-氧代丁酸琥珀酰亚胺酯
948995-62-8 S0808
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流动相添加剂
品名 CAS 货号
Acetic acid, 99.9%, eluent additive for LC-MS
乙酸
64-19-7 918896
危化品
Ammonium acetate, 99%, eluent additive for LC-MS
乙酸铵
631-61-8 992378
Ammonium formate, 99%
甲酸铵
540-69-2 932336
Ammonium hydroxide, 25 wt% solution in H2O, eluent additive for LC-MS
氢氧化铵
1336-21-6 951102
危化品
Formic acid, 98%, for LC-MS
甲酸
64-18-6 942988
危化品
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质谱标准品
品名 CAS 货号
2,4,6-Tris(heptafluoropropyl)-1,3,5-triazine
2,4,6-三(七氟丙基)-1,3,5-三嗪
915-76-4 T0859
2,4,6-Tris(pentadecafluoroheptyl)-1,3,5-triazine
2,4,6-三(全氟庚基)-1,3,5-三嗪
21674-38-4 T896145
2,4,6-Tris(pentafluoroethyl)-1,3,5-triazine
2,4,6-三(五氟乙基)-1,3,5-三嗪
858-46-8 T0858
Heptacosafluorotributylamine [for Mass spectrometry]
二十七氟三丁胺 [质谱分析用]
311-89-7 P0074
质谱基质
品名 CAS 货号
1,8-Dihydroxyanthracen-9(10H)-One
1143-38-0 OR1009295
2-(4-Hydroxyphenylazo)benzoic acid, 98%
2-(4-羟基苯唑)苯甲酸
1634-82-8 604440
2,5-Dihydroxybenzoic acid, 98%
龙胆酸
490-79-9 911841
3,4-Dimethoxycinnamic acid, 99%
3,4-二甲氧基肉桂酸
2316-26-9 125408
3,5-Dimethoxy-4-hydroxycinnamic acid, 98%, predominantly trans isomer
3,5-二甲氧基-4-羟基肉桂酸
530-59-6 397578
3-Aminoquinoline
3-氨基喹啉
580-17-6 OR30967
危化品
3-Hydroxypicolinic acid, 98%
3-羟基-2-吡啶甲酸
874-24-8 559198
9-Aminoacridine, 98%
9-氨基吖啶
90-45-9 108364
alpha-Cyano-3-hydroxycinnamic Acid
α-氰基-3-羟基肉桂酸
54673-07-3 C2677
Caffeic acid, 99%, predominantly trans
咖啡酸
331-39-5 247526
Ferulic acid, 99%
阿魏酸
1135-24-6 408508
α-Cyano-4-hydroxycinnamic acid, 99%
α-氰基-4-羟基肉桂酸
28166-41-8 947196
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临床质谱氘代内标
品名 CAS 货号
17α-Hydroxyprogesterone-d8, 98%, reference material
17α-羟基孕酮-D8
850023-80-2 992010
25-HydroxyvitaminD3-d3, 98%, reference material
25-羟基维生素D3-D3
140710-94-7 993179
4-Androstene-3,17-Dione-d7, 98%, reference material
雄烯二酮-D7
67034-85-9 448065
Acetyl carnitine-d3 HCl, 98%, reference material
乙酰肉碱-D3 盐酸盐
/ 9396811
Decanoyl carnitine-d3 HCl, 98%, reference material
癸酰基肉碱-D3盐酸盐
2483831-87-2 9314219
DL-Alanine-2,3,3,3-d4, 98%, reference material
DL-丙氨酸-2,3,3,3-D4
53795-92-9 448472
Glycine-d2, 98%, reference material
甘氨酸-D2
4896-75-7 480768
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耗材
品名 CAS 货号
C18-H HPLC column, 250*4.6 mm 5 μm, 120 Å, PH 1.5-10.5
C18-H 液相色谱柱
/ 1122769
Centrifuge tubes, 10 mL, round bottom, 200 tubes/pack
离心管
/ 914354
HLB SPE Cartridges, bed wt. 200 mg, volume 6 ml, 30 pcs/pack
HLB 固相萃取小柱
/ 948068
MAX SPE Cartridges, bed wt. 150 mg, volume 6 ml, 30 pcs/pack
MAX 固相萃取小柱
/ 994507
Pipette tips, 200 μL, yellow, low Retention, 1000 tips/pack
移液器吸头
/ 1438546
Short screw thread vial caps and septa, 9 mm blue pp cap, centre hole 6 mm, pre-slit blue PTFE/white silicone septum
短螺纹样品瓶组合盖垫
/ 993144
Short screw thread vials, 2ml, 9mm, 11.6×32mm, with marking spot, amber, wide opening
短螺纹样品瓶, 2ml, 9mm, 11.6×32mm, 棕色, 广口, 带书写签
/ 902590
Single-channel mechanical pipettor, Volume range: 50 - 200 μL, Increment: 1.0 μL
单道手动可调移液器
/ 1122426
Syringe filter, PTFE membrane (hydrophillic), non-sterile, 13mm, 0.45µm, 200 pcs/pack
针头式过滤器
/ 2123704
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其他耗材
品名 CAS 货号
5 mm NMR Economy Sample Tube w/ Cap, 7″, High-Throughput
5毫米,高通量经济型核磁管,7英寸
/ 1001281
Magnetic stir bar, PTFE-coated, cylindrical,without pivot ring, C60 (3mm*6mm), 5 pcs/pack
聚四氟乙烯磁力搅拌子,圆柱型,无轴环
/ 2736330
Crimp-top vials, 2ml, 11.6×32mm, with marking spot,amber, large opening
样品瓶
/ 920035
Laboratory consumables, disposable dispenser for laboratory use (without needle), limited to scientific research use only, 2-piece, pp, 5 ml
实验室耗材, 实验室用一次性加液器(无针头), 仅限科研使用
/ 972645
Centrifuge tubes, 50 ml, scale can stand on a pointed bottom, 25 pieces/bag, 2 bags/bag
离心管
/ 966183
PCR tube caps, suitable for 0.2 ml RTPCR, strips of 8, flat cap, 125 strips/pack
PCR管盖
/ 1438748
TLC aluminum oxide plates (fluorescent indicator), Neutral,F254,200*100 mm, layer thickness: 0.2±0.02, particle size: ≥400 mesh
薄层层析氧化铝板(含荧光)
/ 978011
Wash bottle, 500 ml, bottle: LDPE, cap: PP, 10 pcs/pack
塑料洗瓶
/ 984183
Plastic graduated cylinder, capacity: 50 ml, 1 PAK=12 EA
塑料量筒
/ 2742049
304 Stainless Steel Micro-Spatula, 125mm, one end rounded and hend up, the other end square
304不锈钢药刮
/ 9076550
Pipette fillers, 15 ml, blue, frosted, 20 pcs/pack
洗耳球
/ 1208125
智慧实验室
品名 CAS 货号
FindMolecule ELN, Academic Basic
ELN电子记录本系统服务
/ 9269008
FindMolecule IMS, Academic Basic
实验室库存管理系统服务
/ 9269003
Smart Hazardous Chemical Management Cabinet HCA00, Container size: 900 * 500 * 1980mm, internal size: 650 * 420 * 1550mm, volume 423L
RFID酸碱柜HCA-400
/ 9410144
Bio-Vanguard
品名 CAS 货号
Bio-Vanguard® Disinfectant Spray
清萨灵®消毒剂
/ 916670
Bio-Vanguard® Antimicrobial Rinse-free Foaming Hand Sanitizer
清萨灵®泡沫抗菌免水洗手液
/ 965255
Antibacterial polycotton laboratory coats, L(170-175cm,60-70kg)
涤棉抗菌实验服
/ 966163
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