硒代蛋氨酸（Se-Met）是一种硒的有机形态，与蛋氨酸类似。目前硒代蛋氨酸的生物学研究日趋成熟，可作为医药保健品中间体、饲料添加剂等来调控机体的自由基代谢、抗氧化功能、免疫功能、生殖功能、细胞凋亡和激素分泌^[1-2]。
    在蛋白质研究领域中，硒代蛋氨酸可在不影响蛋白质功能情况下完全替代蛋氨酸，且其衍生物晶体与天然蛋白晶体同晶，用于经典相位确定法——“同晶置换法”进行蛋白结构分析^[3-4]。蛋白质研究中的硒代蛋氨酸标记还可在模型构建时助力确认蛋氨酸残基位点^[5-6]。

    百灵威提供L-硒代蛋氨酸产品，品质优良，现货稳定供应：
高纯度，97%以上；
质量有保障：HPLC检测方法验证；

产品列表

品名	CAS	货号
L-Selenomethionine, 97% L-硒代蛋氨酸	3211-76-5	207744

相关产品

品名	CAS	货号
Isopropyl β-D-thiogalactopyranoside, 98%, reagent grade 异丙基 β-D-硫代半乳糖吡喃糖苷	367-93-1	958052
Peptone 蛋白胨	73049-73-7	146972
Tris(hydroxymethyl)aminomethane, 99.5%, extra pure 三(羟甲基)氨基甲烷	77-86-1	226162
Sodium chloride, 99.5%, molecular biology grade 氯化钠	7647-14-5	908606
Imidazole, 99%, reagent grade 咪唑	288-32-4	570747
Phosphoric acid, 85% solution in H2O, ACS reagent 磷酸	7664-38-2	933962 危化品
Ethanol, 99.7%, reagent grade, anhydrous 乙醇	64-17-5	983081 危化品
Coomassie Brilliant Blue G, for electrophoresis 考马斯亮蓝G	6104-58-1	327499
Bromophenol Blue, for analysis, Indicator 溴酚蓝	115-39-9	978967
Sodium dodecyl sulfate, 99%, for biochemistry 十二烷基硫酸钠	151-21-3	105893促
Glycerol, 99%, for bio 甘油	56-81-5	921371
DL-Dithiothreitol, 98%, for bio DL-二硫苏糖醇	3483-12-3	963376
Ampicillin sodium salt 氨苄青霉素钠	69-52-3	947040
Kanamycin sulfate, an aminoglycoside bacteriocidal antibiotic which acts by binding to the bacterial 30S ribosomes 硫酸卡那霉素	25389-94-0	357211
Sodium hydroxide, 96%, for analysis 氢氧化钠	1310-73-2	904646 危化品
α-Toluenesulfonyl fluoride, 98.5% α-甲苯基磺酰氟	329-98-6	945600

生化耗材

品名	CAS	货号
Single-channel mechanical pipettor, Volume range: 0.5 - 10 μL, Increment: 0.1 μL 单道手动可调移液器	/	1122421
Single-channel mechanical pipettor, Volume range: 100 - 1000 μL, Increment: 5.0 μL 单道手动可调移液器	/	1122427
Single-channel mechanical pipettor, Volume range: 20 - 200 μL, Increment: 1.0 μL 单道手动可调移液器	/	954106
Centrifuge tubes, 1.5 mL, clear, 500 tubes/pack 离心管	/	915664
Pipette tips, 10 μL, clear, 1000 tips/pack 移液器吸头	/	920067
Pipette tips, 1000 μL, blue, 1000 tips/pack 移液器吸头	/	672890
Pipette tips, 200 μL, yellow, 1000 tips/pack 移液器吸头	/	970956

其他产品

品名	CAS	货号
Antibacterial 100% Cotton laboratory coats, men, M (165~170cm, 50-60 kg), long-sleeved 抗菌纯棉实验服	/	9307384
Antibacterial 100% Cotton laboratory coats, men, L (170-175cm, 60-70 kg), long-sleeved 抗菌纯棉实验服	/	9307387
FindMolecule ELN, Academic Basic ELN电子记录本系统服务	/	9269008
FindMolecule IMS, Academic Basic 实验室库存管理系统服务	/	9269003

参考文献

1. Siyu Li,Zhaorong Ouyang,Mengjie Zhang, et al.Selenomethionine-Conjugated Extracellular Vesicles for ROS-Mediated Cell Apoptosis[J].ACS Applied Nano Materials,2024, 7(12): 20.
2. Jun Chen,Yinzhi Zhang,Yantao Lv,et al.Effects of Selenomethionine on Cell Viability,Selenoprotein Expression and Antioxidant Function in Porcine Mammary Epithelial Cells[J]. Frontiers in Nutrition,2021,8:665855.
3. Rebecca Notis Dardashti,Norman Metanis, et al.Revisiting ligation at selenomethionine: Insights into native chemical ligation at selenocysteine and homoselenocysteine[J]. Bioorganic & Medicinal Chemistry,2017,25(18): 4983-4989.
4. Daniele de Sanctis, Paul A Tucker, Santosh Panjikar, et al. Additional phase information from UV damage of selenome­thionine labelled proteins[J]. Journal of Synchrotron Radiation,2011,18: 374-380.
5. John Q Bettinger, Kevin A Welle, Jennifer R Hryhorenko, et al. Quantitative Analysis of in Vivo Methionine Oxidation of the Human Proteome[J].Journal of Proteome Research ,2019, 19 (2).
6. Ronnie P.-A. Berntsson, Nur Alia Oktaviani,Fabrizia Fusetti,et al.Selenomethionine incorporation in proteins expressed in Lactococcus lactis[J].Protein Science,2009,18(5): 1121-1127.

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