肿瘤代谢与转移相关活性小分子化合物-百灵威

代谢异常是肿瘤的关键特征之一，表现为物质合成代谢途径的增加以及有氧糖酵解。肿瘤代谢的灵活性和可塑性对于肿瘤细胞的存活和增长是至关重要的。近年来，研究者们提出了关于肿瘤转移的代谢适应机制，揭示了肿瘤代谢与转移间的广泛联系。

多种营养物质能促进肿瘤转移中代谢物的可塑性。如肿瘤细胞会吸收谷氨酰胺，通过氮或碳代谢途径将其转化为非必需氨基酸和核苷酸。抑制代谢途径中的关键酶的功能可以抑制癌细胞的增殖。如，降低乳酸脱氢酶A或B的表达可以抑制乳腺癌细胞的体外迁移。

百灵威提供肿瘤代谢与转移研究中的小分子化合物，

品名	CAS	货号
A 769662, 98%, a potent, reversible AMPK activator with EC50 of 0.8 μM A 769662	844499-71-4	1386067
ABT-737, 98%, a selective and BH3 mimetic Bcl-2, Bcl-xL and Bcl-w inhibitor with EC50s of 30.3 nM, 78.7 nM, and 197.8 nM, respectively. ABT-737	852808-04-9	831900
Acetylcholine chloride, 98% 氯化乙酰胆碱	60-31-1	249495
N-Acetyl-L-cysteine, 99% N-乙酰基-L-半胱氨酸	616-91-1	114448
Adenosine, 99% 腺苷	58-61-7	132283
SB 203580, 98%, a selective and ATP-competitive p38 MAPK inhibitor SB 203580抑制剂	152121-47-6	176239
R-Afatinib, 98%, an irreversible EGFR family inhibitor with IC50s of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively R-阿法替尼	850140-72-6	996037
AG-490, 99%, an inhibitor of EGFR 酪磷蛋白 AG-490	133550-30-8	597344
Ammonium chloride, 99.6%, ACS reagent 氯化铵	12125-02-9	934775
Ferric ammonium citrate, 17.5 - 22.5% Fe 柠檬酸铁铵	1185-57-5	388571
Anisomycin, 99%, from Streptomyces griseolus, a JNK activator, which increases phospho-JNK 茴香霉素	22862-76-6	443310
Apigenin, 98% 芹菜素	520-36-5	470737
Aprotinin, 6000 U/mg 抑肽酶	9087-70-1	398539
Artesunate, 98%, an inhibitor of both STAT-3 and exported protein 1 (EXP1) 青蒿琥酯	88495-63-0	173925

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2-Amino-9H-pyrido[2,3-b]indole, 98% 2-氨基-9H-吡啶[2,3-b]吲哚	26148-68-5	399953
7,12-Dimethylbenz[a]anthracene, 98.5% 7,12-二甲基苯并[a]蒽	57-97-6	471138
4-Nitroquinoline N-oxide, 98% 4-硝基喹啉-N-氧化物	56-57-5	164927
β-Estradiol, 99%, Estrogen receptor β-雌二醇	50-28-2	228703
(-)-Epicatechin, 98%, reference material (-)-表儿茶素	490-46-0	563013
Benzo[a]pyrene, 96% 苯并[a]芘	50-32-8	963442
N-Nitroso-N-methylurea, 95%, stabilized 0.05% H2SO4,about 10% water content N-甲基-N-亚硝基脲	684-93-5	902978
Aflatoxin B1, 98%, reference material 黄曲霉毒素 B1	1162-65-8	477564
N-Nitrosodiethylamine, 99% N-亚硝基二乙胺	55-18-5	400542
Benzo[a]phenanthrene, 99% 苯并[a]菲	218-01-9	283718
4-(N-Methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone, 98% 4-(N-甲基-N-亚硝氨基)-1-(3-吡啶基)-1-丁酮	64091-91-4	580814
Urethane, 98.5% 氨基甲酸乙酯	51-79-6	251263
Nitrofurazone, 98% 呋喃西林	59-87-0	612667
Terephthalic acid, 99% 对苯二甲酸	100-21-0	333492

品名	CAS	货号
DMEM, high glucose DMEM, 高糖	/	924551
MEM, Reduced serum medium MEM, 减血清培养基	/	9328570
RPMI 1640 RPMI 1640细胞培养基	/	9328571

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CarpTrans Transfection Reagent CarpTrans转染试剂	/	9306635
Lip2000 Transfection Reagent Lip2000 转染试剂	/	1912568

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Agarose, low EEO 合成琼脂糖	9012-36-6	950081
Bovine serum albumin, 98%, from bovine serum 牛血清白蛋白	9048-46-8	900523
Bovine serum albumin, 98%, Australia origin, low IgG, low fatty acid 牛血清白蛋白	9048-46-8	109636
Crystal Violet, high purity biological stain 结晶紫	548-62-9	179783
4',6-Diamidino-2-phenylindole dihydrochloride, 98% 4',6-二脒基-2-苯基吲哚二盐酸盐	28718-90-3	560965

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L-Glutamine, 99% L-谷氨酰胺	56-85-9	160938
Puromycin dihydrochloride, 98% 嘌呤霉素二盐酸盐	58-58-2	168086

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Acetonitrile, 99.9%, HPLC/ACS 乙腈	75-05-8	134752 危化品
Methanol, 99.9%, HPLC/ACS 甲醇	67-56-1	116481 危化品
Tetrahydrofuran, 99.9%, ACS/HPLC Certified, unstabilized 四氢呋喃	109-99-9	168395 危化品

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Single-channel mechanical pipettor, Volume range: 0.5 - 10 μL, Increment: 0.1 μL 单道手动可调移液器	/	1122421
Single-channel mechanical pipettor, Volume range: 100 - 1000 μL, Increment: 5.0 μL 单道手动可调移液器	/	1122427
Single-channel mechanical pipettor, Volume range: 20 - 200 μL, Increment: 1.0 μL 单道手动可调移液器	/	954106
Centrifuge tubes, 1.5 mL, clear, 500 tubes/pack 离心管	/	915664
Pipette tips, 10 μL, clear, 1000 tips/pack 移液器吸头	/	920067
Pipette tips, 1000 μL, blue, 1000 tips/pack 移液器吸头	/	672890
Pipette tips, 200 μL, yellow, 1000 tips/pack 移液器吸头	/	970956

肿瘤代谢与转移相关活性小分子化合物