Ullmann Reaction
时间: 2020-11-20
作者: 百灵威
分享:
The Ullmann reaction uses copper metal to convert aryl halides to biaryl compounds. The mechanism is not yet fully understood, but there are two theories in consideration. The radical mechanism involves a single electron transfer (SET) to form aryl radicals that combine to produce the biaryl product. The second mechanism involves two oxidative additions and an SET to yield a Cu(III) intermediate. Reductive elimination affords the biaryl product.
- Reagents: Cu Metal or Cu(I)-Salts in 1-5 Equiv (e.g. Cu2O, Cu2S)
- Reactant: Halogenated Benzene or Heteroaromatic Compound (2 Equiv)
- Product: Symmetrical Biaryl (with Cu-Powder) or Unsymmetrical Biaryl (with Cu(I)-Salt)
- Type of Reaction: Cu-Mediated Coupling
Mechanism
Original Paper
Top Citations
Related Reactions
Related Compounds
服务科技与工业发展 造福人类
关注微信公众号
北京市朝阳区北辰西路69号峻峰华亭A座5层 100029
电话(QQ): 400 666 7788
电话：+86 10 59309000
传真：+86 10 8284 9933
本网站销售的化学产品仅供研发或工业应用，不直接用于食品、药品、临床诊断或治疗。
