肿瘤免疫抑制微环境严重削弱机体抗癌能力，降低药物疗效，加速肿瘤恶化转移。其中，骨髓来源的抑制性细胞（MDSCs）通过抑制细胞毒性T淋巴细胞（CD8+ T细胞）激活，阻碍免疫系统对肿瘤的识别与清除，成为肿瘤进展的关键因素。因此，开发能同步抑制MDSCs浸润、激活CD8+ T细胞的疗法极具临床意义。

PRA@Oxa-c16 的制备及抗肿瘤示意图.

    中国科学院化学研究所肖海华课题组深耕生物医用材料领域，在四价铂类纳米药物抗癌研究中取得重要成果。团队设计合成双亲性高分子PolyRA与四价铂前药Oxa-c16，组装成 PRA@Oxa-c16 纳米粒。该纳米粒可有效抑制MDSCs向肿瘤部位聚集，诱导免疫原性细胞死亡，显著增强CD8+ T细胞的抗癌活性。联合α PD-L1抗体使用时，不仅能清除小鼠皮下肿瘤、抑制肺转移，还大幅降低肿瘤复发风险，为肿瘤免疫治疗提供了新策略。

    百灵威销售肖海华课题组四价铂类前药和聚合物产品，产品优势如下：

    广谱抗癌活性的化合物

    固体，易于保存

    性质稳定、操作安全

    应用范围广，反应高效

化合物结构

四价铂前药-1.

四价铂前药-2.

四价铂前药-3.

聚合物1.

聚合物2.

聚合物3.

聚合物4.

聚合物5.

聚合物6.

聚合物7.

聚合物8.

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常用试剂推荐

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智慧实验室

Bio-Vanguard

肖海华课题组成果文献：

1. Wang B, Tang D S, Karges J, Cui M H, Xiao H H. A NIR‐II Fluorescent PolyBodipy Delivering Cationic Pt‐NHC with Type II Immunogenic Cell Death for Combined Chemotherapy and Photodynamic Immunotherapy[J]. Advanced Functional Materials, 2023, 33(30)
2. Wei D S, Huang Y, Wang B, Ma L L, Karges J, Xiao H H. Photo‐Reduction with NIR Light of Nucleus‐Targeting PtIV Nanoparticles for Combined Tumor‐Targeted Chemotherapy and Photodynamic Immunotherapy[J]. Angewandte Chemie International Edition, 2022, 61(20)
3. Tang D S, Zhou H L, Cui M H, Liang G H, Zhang H C, Xiao H H. NIR‐II Light Accelerated Prodrug Reduction of Pt(IV)‐Incorporating Pseudo Semiconducting Polymers for Robust Degradation and Maximized Photothermal/Chemo‐Immunotherapy[J]. Advanced Materials, 2023, 35(30)
4. Cui M H, Tang D S, Zhang H C, Liang G H, Xu C, Xiao H H. NIR‐II Fluorescent Nanotheranostics with a Switchable Irradiation Mode for Immunogenic Sonodynamic Therapy[J]. Advanced Materials, 2024
5. Cui M H, Tang D S, Wang B, Zhang H C, Liang G H, Xiao H H. Bioorthogonal Guided Activation of cGAS-STING by AIE Photosensitizer Nanoparticles for Targeted Tumor Therapy and Imaging[J]. Advanced Materials, 2023
6. Tang D S, Cui M H, Wang B, Liang G H, Zhang H C, Xiao H H. Nanoparticles destabilizing the cell membranes triggered by NIR light for cancer imaging and photo - immunotherapy[J]. Nature Communications, 2024, 15(1)
7. Wang W K, Yang F Y, Zhang L P, Wang M S, Yin L, Dong X Y, Xiao H H, Xing N Z. Targeting DNA Damage and Repair Machinery via Delivering WEE1 Inhibitor and Platinum (IV) Prodrugs to Stimulate STING Pathway for Maximizing Chemo‐Immunotherapy in Bladder Cancer[J]. Advanced Materials, 2024, 36(2)
8. Ding F X, Liu J Y, Ai K L, Xu C, Mao X Y, Liu Z Q, Xiao H H. Simultaneous Activation of Pyroptosis and cGAS‐STING Pathway with Epigenetic/Photodynamic Nanotheranostic for Enhanced Tumor Photoimmunotherapy[J]. Advanced Materials, 2024, 36(8)

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